Format

Send to:

Choose Destination
See comment in PubMed Commons below
Environ Health. 2011 Mar 10;10:15. doi: 10.1186/1476-069X-10-15.

Effect of hourly concentration of particulate matter on peak expiratory flow in hospitalized children: a panel study.

Author information

  • 1Department of Epidemiology and Healthcare Research, Kyoto University School of Public Health, Yoshidakonoe-cho, Sakyo-ku, Kyoto, Japan. yamazaki.shin@kt8.ecs.kyoto-u.ac.jp

Abstract

BACKGROUND:

Little information is available on the possible association between hourly short-term air pollution and peak expiratory flow (PEF) in asthmatic children.

METHODS:

PEF was measured twice daily, from October through December, 2000, in 17 children aged 8 to 15 years hospitalized with severe asthma. A total of 1198 PEF measurements were made at 7 a.m. and 1175 at 7 p.m. Measurements were conducted immediately prior to medication under the guidance of trained nurses. PEF changes were estimated in 10-μg/m3 increments of particulate matter with a 50% cut-off aerodynamic diameter of ≤2.5 μm (PM2.5), with adjustment for sex, age, height, and temperature. Lagged-hour exposures of up to 24 hours were examined.

RESULTS:

Increased 24-hour mean concentration of PM2.5 was associated with a decrease in both morning and evening PEF (-3.0 l/minute; 95%CI: -4.6, -1.4 and -4.4 l/minute; 95%CI: -7.1, -1.7, respectively). In addition, hourly concentrations of PM2.5 and PEF showed a significant association between some lags of PM2.5 and PEF. Effect size was almost -3 l/minute in both morning and evening PEF for an hourly PM2.5 concentration of 10 μg/m3 in several lags. Even after adjustment for other air pollutants, some of the significant associations with PEF remained.

CONCLUSION:

Among hospitalized children with severe asthma, increased hourly concentration of PM2.5 was associated with a decrease in PEF.

PMID:
21392385
[PubMed - indexed for MEDLINE]
PMCID:
PMC3061887
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Write to the Help Desk