The challenge of relating gene expression to the virulence of Salmonella enterica serovar Typhimurium

Magali Hébrard; Carsten Kröger; Sathesh K Sivasankaran; Kristian Händler; Jay C D Hinton

doi:10.1016/j.copbio.2011.02.007

The challenge of relating gene expression to the virulence of Salmonella enterica serovar Typhimurium

Curr Opin Biotechnol. 2011 Apr;22(2):200-10. doi: 10.1016/j.copbio.2011.02.007. Epub 2011 Mar 22.

Authors

Magali Hébrard¹, Carsten Kröger, Sathesh K Sivasankaran, Kristian Händler, Jay C D Hinton

Affiliation

¹ Department of Microbiology, Moyne Institute of Preventive Medicine, School of Genetics & Microbiology, Trinity College, Dublin 2, Ireland.

PMID: 21388802
DOI: 10.1016/j.copbio.2011.02.007

Abstract

The first decade of transcriptomic studies of Salmonella enterica serovar Typhimurium focused upon gene expression in vitro, and during the infection of mammalian cells. The published regulons and stimulons show that the three Type Three Secretion Systems of S. Typhimurium respond to a diverse range of environmental conditions, and are controlled by a hierarchy of regulatory proteins. The integration of in vitro generated transcriptomic data with global gene expression of S. Typhimurium during infection is beginning to yield valuable information. The coordinated regulation of Salmonella gene expression is a key process for survival, adaptation and virulence capacities of the pathogen.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Food Microbiology / methods
Gene Expression Regulation, Bacterial / genetics
Gene Expression Regulation, Bacterial / physiology*
Salmonella typhimurium / genetics
Salmonella typhimurium / metabolism*
Salmonella typhimurium / pathogenicity*
Virulence / genetics
Virulence / physiology*