Lithium interaction network. A seed of 18 Group 1 differentially regulated lithium targets was uploaded into MiMI Cytoscape plugin and a network was generated using the “query genes + nearest neighbor” option. The interaction network is presented as the Cytoscape degree sorted circle summary layout; the nodes, shown as circles, form a chain within the periphery of the large circle and the edges are shown as lines linking two nodes. The largest 25 hubs were manually extended away from the network circle to reveal the node labels. Edges for the top 5 hubs are shown in different colors. Lists of 492 nodes and 3101 edges are available upon request.

Figure 3A Enriched pathways recruited by lithium network nodes. Bars are colored to indicate those pathways containing or lacking one or a combination of AKT1/2, MAPK1/3 and GSK3B. Red bars represent pathways that contain AKT1/2, MAPK1/3 and GSK3B; purple bars include AKT1/2 and MAPK1/3; yellow bars contain AKT1/2; green bars contain GSK3B; AKT1/2, MAPK1/3 and GSK3B are absent in pathways represented by black bars and blue bars contain MAPK1/3; sky blue bars contain both GSK3B and MAPK1/3. Abbreviations: AJ=adherens junction; BCR=B cell receptor signaling; ECSHPI=epithelial cell signaling in Helicobacter pylori infection; FA=focal adhesion; FceRI=Fc epsilon RI signaling; FcgRMP=Fc gamma R-mediated phagocytosis; GJ=gap junction; LTD=long term depression; LTM=leukocyte transendothelial migration; LTP=long term potentiation; NKCMC=natural killer cell mediated cytotoxicity; NOD-like R=NOD-like receptor; OM=oocyte meiosis; P-MOM=progesterone mediate oocyte maturation; TCR=T cell receptor signaling; Toll-like R=Toll-like receptor signaling. Lists of nodes populating individual pathways are available upon request.
Figure 3B Enriched pathways recruited by valproate network nodes. Representations are as in Figure 3A.
Figure 3C Enriched pathways recruited by lithium-valproate intersecting network nodes. Representations are as in Figure 3A.

Valproate interaction network. A seed of 47 differentially regulated valproate targets was uploaded into MiMI Cytoscape plugin and a network was generated using the “query genes + nearest neighbor” option. The interaction network is presented as in Figure 1. Lists of 897 nodes and 7849 edges are available upon request.

Figure 4A Subclusters extracted from the large lithium network. Smaller complexes were generated by using the Community Clustering algorithm, GLay. Seed molecules included in each cluster are in yellow and subclusters are color coded.
Figure 4B Subclusters extracted from the large valproate network. Smaller complexes were generated by using the Community Clustering algorithm, GLay. Seed molecules included in each cluster are in yellow and subclusters are color coded.