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J Pediatr Hematol Oncol. 2011 Apr;33(3):e125-6. doi: 10.1097/MPH.0b013e3182036e06.

New onset psychosis in an adolescent during treatment of testicular germ cell tumor.

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  • 1Department of Pediatrics, Department of Pediatrics, The University of Kansas Medical Center, Kansas City, KS, USA.


Germ cell tumor of the testis is the most common malignancy in young males between 15 and 45 years of age. Side effects of treatment are common, but psychiatric reactions have not been reported. We describe a case of a 16-year-old male patient with nonseminomatous germ cell tumor of the testis treated with orchiectomy and bleomycin, etoposide, and cisplatin chemotherapy. Treatment was complicated by the development of psychosis after first chemotherapy cycle. Etiology of psychosis was most likely multifactorial including stress related to cancer diagnosis and treatment, psychosocial and family stressors, history of traumatic brain injury, and corticosteroid medication.

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