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Behav Brain Res. 2011 Sep 12;222(1):265-9. doi: 10.1016/j.bbr.2011.02.043. Epub 2011 Mar 5.

Enhanced long-term fear memory and increased anxiety and depression-like behavior after exposure to an aversive event in mice lacking TIP39 signaling.

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  • 1Section on Fundamental Neuroscience, NIMH, National Institutes of Health (NIH), 35 Convent Drive, 20892 Bethesda, MD, USA.


Exaggerated recall for fear-provoking events leads to abnormal behaviors. We hypothesized that tuberoinfundibular-peptide-of-39-residues (TIP39) modulates fear memory by limiting long-term consequences of aversive experiences. We now show that mice lacking TIP39 signaling display enhanced fear-recall, anxiety and depression-like behavior 2 weeks after a traumatic event. We suggest that TIP39 modulates long-term fear recall and that mice lacking TIP39 or its receptor are tools for investigating fear-related psychopathologies.

Published by Elsevier B.V.

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