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Oncotarget. 2011 Jan-Feb;2(1-2):76-88.

Targeting translation dependence in cancer.

Author information

  • 1Department of Biochemistry, McIntyre Medical Sciences Building, McGill University, Montreal, Quebec, Canada.

Abstract

A challenge in cancer therapy is to selectively target activities that are essential for survival of malignant cells while sparing normal cells. Translational control represents a potential anti-neoplastic target because it is exerted by major signaling pathways that are often usurped in cancers. Herein we describe approaches being developed that target eukaryotic initiation factor (eIF) 4F, a heterotrimeric complex that integrates multiple signaling inputs to the translation apparatus.

PMID:
21378410
[PubMed - indexed for MEDLINE]
PMCID:
PMC3248143
Free PMC Article
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