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J Bacteriol. 2011 May;193(9):2332-5. doi: 10.1128/JB.00027-11. Epub 2011 Mar 4.

Whole-genome sequencing of Staphylococcus aureus strain RN4220, a key laboratory strain used in virulence research, identifies mutations that affect not only virulence factors but also the fitness of the strain.

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  • 1Department of Microbiology, Dartmouth Medical School, Hanover, NH 03755, USA.

Abstract

Staphylococcus aureus RN4220, a cloning intermediate, is sometimes used in virulence, resistance, and metabolic studies. Using whole-genome sequencing, we showed that RN4220 differs from NCTC8325 and contains a number of genetic polymorphisms that affect both virulence and general fitness, implying a need for caution in using this strain for such studies.

PMID:
21378186
[PubMed - indexed for MEDLINE]
PMCID:
PMC3133102
Free PMC Article

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