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Med Dosim. 2011 Winter;36(4):389-96. doi: 10.1016/j.meddos.2010.09.008. Epub 2011 Mar 5.

Helical tomotherapy planning for lung cancer based on ventilation magnetic resonance imaging.

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  • 1Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908, USA.

Abstract

To investigate the feasibility of lung ventilation-based treatment planning, computed tomography and hyperpolarized (HP) helium-3 (He-3) magnetic resonance imaging (MRI) ventilation images of 6 subjects were coregistered for intensity-modulated radiation therapy planning in Tomotherapy. Highly-functional lungs (HFL) and less-functional lungs (LFL) were contoured based on their ventilation image intensities, and a cylindrical planning-target-volume was simulated at locations adjacent to both HFL and LFL. Annals of an anatomy-based plan (Plan 1) and a ventilation-based plan (Plan 2) were generated. The following dosimetric parameters were determined and compared between the 2 plans: percentage of total/HFL volume receiving ≥20 Gy, 15 Gy, 10 Gy, and 5 Gy (TLV(20), HFLV(20), TLV(15), HFLV(15), TLV(10), HFLV(10), TLV(5), HFLV(5)), mean total/HFL dose (MTLD/HFLD), maximum doses to all organs at risk (OARs), and target dose conformality. Compared with Plan 1, Plan 2 reduced mean HFLD (mean reduction, 0.8 Gy), MTLD (mean reduction, 0.6 Gy), HFLV(20) (mean reduction, 1.9%), TLV(20) (mean reduction, 1.5%), TLV(15) (mean reduction, 1.7%), and TLV(10) (mean reduction, 2.1%). P-values of the above comparisons are less than 0.05 using the Wilcoxon signed rank test. For HFLV(15), HFLV(10), TLV(5), and HTLV(5), Plan 2 resulted in lower values than plan 1 but the differences are not significant (P-value range, 0.063-0.219). Plan 2 did not significantly change maximum doses to OARs (P-value range, 0.063-0.563) and target conformality (P = 1.000). HP He-3 MRI of patients with lung disease shows a highly heterogeneous ventilation capacity that can be utilized for functional treatment planning. Moderate but statistically significant improvements in sparing functional lungs were achieved using helical tomotherapy plans.

Published by Elsevier Inc.

PMID:
21377866
[PubMed - indexed for MEDLINE]
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