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Cell Calcium. 2011 Aug;50(2):129-38. doi: 10.1016/j.ceca.2011.01.010. Epub 2011 Mar 5.

Acidic calcium stores of Saccharomyces cerevisiae.

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  • 1Department of Biology, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA. kwc@jhu.edu

Abstract

Fungi and animals constitute sister kingdoms in the eukaryotic domain of life. The major classes of transporters, channels, sensors, and effectors that move and respond to calcium ions were already highly networked in the common ancestor of fungi and animals. Since that time, some key components of the network have been moved, altered, relocalized, lost, or duplicated in the fungal and animal lineages and at the same time some of the regulatory circuitry has been dramatically rewired. Today the calcium transport and signaling networks in fungi provide a fresh perspective on the scene that has emerged from studies of the network in animal cells. This review provides an overview of calcium signaling networks in fungi, particularly the model yeast Saccharomyces cerevisiae, with special attention to the dominant roles of acidic calcium stores in fungal cell physiology.

2011 Elsevier Ltd. All rights reserved.

PMID:
21377728
[PubMed - indexed for MEDLINE]
PMCID:
PMC3137693
Free PMC Article
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