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Curr Opin Biotechnol. 2011 Oct;22(5):634-47. doi: 10.1016/j.copbio.2011.01.011. Epub 2011 Mar 4.

Metabolic engineering of Clostridium acetobutylicum: recent advances to improve butanol production.

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  • 1Department of Microbiology, Institute of Biological Sciences, University of Rostock, Albert Einstein-Str. 3, 18051 Rostock, Germany.

Abstract

The biosynthesis of the solvents 1-butanol and acetone is restricted to species of the genus Clostridium, a diverse group of Gram-positive, endospore forming anaerobes comprising toxin-producing strains as well as terrestrial non-pathogenic species of biotechnological impact. Among solventogenic clostridia, Clostridium acetobutylicum represents the model organism and general but yet important genetic tools were established only recently to investigate and understand the complex life cycle-accompanied physiology and its regulatory mechanisms. Since clostridial butanol production regained much interest in the past few years, different metabolic engineering approaches were conducted--although promising and in part successful strategies were employed, the major breakthrough to generate an optimum phenotype with superior butanol titer, yield and productivity still remains to be expected.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21377350
[PubMed - indexed for MEDLINE]
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