Format

Send to:

Choose Destination
See comment in PubMed Commons below
Biochim Biophys Acta. 2011 Oct;1812(10):1263-71. doi: 10.1016/j.bbadis.2011.02.008. Epub 2011 Mar 2.

Cilium, centrosome and cell cycle regulation in polycystic kidney disease.

Author information

  • 1Department of Medicine, The Mount Sinai School of Medicine, New York, NY, USA.

Abstract

Polycystic kidney disease is the defining condition of a group of common life-threatening genetic disorders characterized by the bilateral formation and progressive expansion of renal cysts that lead to end stage kidney disease. Although a large body of information has been acquired in the past years about the cellular functions that characterize the cystic cells, the mechanisms triggering the cystogenic conversion are just starting to emerge. Recent findings link defects in ciliary functions, planar cell polarity pathway, and centrosome integrity in early cystic development. Many of the signals dysregulated during cystogenesis may converge on the centrosome for its central function as a structural support for cilia formation and a coordinator of protein trafficking, polarity, and cell division. Here, we will discuss the contribution of proliferation, cilium and planar cell polarity to the cystic signal and will analyze in particular the possible role that the basal bodies/centrosome may play in the cystogenetic mechanisms. This article is part of a Special Issue entitled: Polycystic Kidney Disease.

Copyright © 2011 Elsevier B.V. All rights reserved.

PMID:
21376807
[PubMed - indexed for MEDLINE]
PMCID:
PMC3138898
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Write to the Help Desk