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OMICS. 2011 Mar;15(3):133-9. doi: 10.1089/omi.2010.0111.

Progress in mining the human proteome for disease applications.

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  • 1Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA.


Currently available technologies allow in-depth analysis of multiple facets of the proteome that have clinical relevance and that complement current genomics-based approaches. Although some progress has been made in our knowledge of the human proteome in health and in disease, there is an urgent need to chart a coherent road map with clearly defined milestones to guide proteomics efforts. Areas of emphasis include: (1) building resources, (2) filling gaps in our understanding of biological variation, and (3) systematically characterizing proteome alterations that occur in well-defined disease states, all of which require an organized and collaborative effort.

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