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Nature. 1990 Jan 25;343(6256):341-6.

Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist.

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  • 1Synergen Inc., Boulder, Colorado 80301.


Human monocytes induced with adherent IgG secrete an interleukin-1 receptor antagonist which could be important for the in vivo regulation of IL-1 activity. A complementary DNA for this molecule has been isolated from a human monocyte library. Analysis of monocyte RNA indicates that the gene is transcriptionally regulated. The sequence of the receptor antagonist indicates that it is structurally similar to IL-1 beta. Expression of the cDNA in Escherichia coli yields IL-1 receptor antagonist activity.

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