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Nature. 1990 Jan 25;343(6256):336-40.

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor.

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  • 1Synergen Inc., Boulder, Colorado 80301.


Three interleukin-1 inhibitors have been purified to homogeneity from medium conditioned by human monocytes. Partial sequence analysis and digestion with N-glycanase indicate that these are glycosylation forms of a single protein. The protein binds to the interleukin-1 receptor but has no interleukin-1-like activity, even at very high concentrations, and is therefore a pure receptor antagonist.

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