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Trends Immunol. 2011 Apr;32(4):180-6. doi: 10.1016/j.it.2011.01.004. Epub 2011 Mar 2.

Cytokines and the inception of CD8 T cell responses.

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  • 1Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, United States.

Abstract

The activation and differentiation of CD8 T cells is a necessary first step that endows these cells with the phenotypic and functional properties required for the control of intracellular pathogens. The induction of the CD8 T cell responses typically results in the development of a massive overall population of effector cells, comprising both highly functional but short-lived terminally differentiated cells, as well as a smaller subset of precursors that are predisposed to survive and transition into the memory T cell pool. In this review, we discuss how inflammatory cytokines and IL-2 bias the initial response towards short-lived effector generation, and also highlight the potential counterbalancing role of IL-21.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21371940
[PubMed - indexed for MEDLINE]
PMCID:
PMC3074938
Free PMC Article
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