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Semin Thromb Hemost. 2011 Mar;37(2):106-10. doi: 10.1055/s-0030-1270335. Epub 2011 Mar 2.

Thrombophilia and pre-eclampsia.

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  • 1Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands. m.demaat@erasmusmc.nl


Pre-eclampsia (P-EC) poses an increased risk for fetal and maternal morbidity and sometimes even mortality. Several risk factors have been identified, among which an important extensively studied group is formed by the early recognizable genetic factors resulting in thrombophilia. The discussion is ongoing whether the associations found for thrombophilia are true and clinically relevant. In this review, we address the association between P-EC and thrombophilia, its concerns, and the necessity of screening after a pregnancy complicated by hypertension.

© Thieme Medical Publishers.

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