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Gan To Kagaku Ryoho. 2010 Dec;37 Suppl 2:293-5.

[Effects of packaging forms on the stability of vitamin B1 and vitamin C in TPN admixtures].

[Article in Japanese]

Author information

  • 1Information Center for Infusion Therapy and Product, Otsuka Pharmaceutical Factory, Inc.

Abstract

In order to reduce a microbial contamination and needle stick injuries that are associated with a mixing procedure in home parentera nutrition(HPN), nutrition(TPN)solution bags pre-mixed with trace elements may be provided in a form of outer packaging. On the other hand, a packaging form used to enclose the TPN bag after admixture may significantly affect the stability of vitamins. With a focus on possible decrease in vitamin B1 and C content, we investigated the effects of the packaging form. As a result, the TPN bag, which is packed in a light-resistant outer wrap of oxygen-barrier film with an oxygen absorbent under reduced pressure, suppressed a decrease in vitamin content most. However, the decrease in vitamin C content was observed when there was a long time-lag between a preparation and a packaging. We thought it was desirable to pack the TPN bag promptly after the preparation.

PMID:
21368554
[PubMed - indexed for MEDLINE]
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