Gan To Kagaku Ryoho. 2011 Jan;38(1):109-12.

[A case of complete response of gemcitabine (GEM) monotherapy-refractive liver metastatic pancreatic cancer treated with GEM+S-1 combined chemotherapy].

[Article in Japanese]

Hatata T, Takaya S, Taniguchi K, Naka T, Kondo A, Ikeguchi M.

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Dept. of Surgery, Graduate School of Medicine, Tottori University, Japan.

Abstract

A 75-year-old man with pancreatic body cancer underwent distal pancreatectomy and was treated with gemcitabine (GEM) as an adjuvant therapy. Multiple liver metastases appeared three months after the surgery. With GEM+S-1 combined chemotherapy, liver metastatic lesions became unidentifiable upon imaging 7 months later. Complete response status had continued as long as 13 months. Though grade 3 neutropenia appeared after 2 courses of the combined therapy, the patient well tolerated it after controlling the dosing schedule. The GEM+S-1 combined chemotherapy was expected to have synergistic effects for GEM monotherapy-refractive pancreatic cancer.

PMID:: 21368469; [PubMed - indexed for MEDLINE]

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