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Curr Opin Biotechnol. 2011 Jun;22(3):337-43. doi: 10.1016/j.copbio.2011.02.004. Epub 2011 Mar 1.

Fermentative production of butanol--the industrial perspective.

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  • 1Green Biologics Ltd., 45A Milton Park, Abingdon, Oxfordshire OX14 4RU, United Kingdom.


A sustainable bacterial fermentation route to produce biobutanol is poised for re-commercialization. Today, biobutanol can compete with synthetic butanol in the chemical market. Biobutanol is also a superior biofuel and, in longer term, can make an important contribution towards the demand for next generation biofuels. There is scope to improve the conventional fermentation process with solventogenic clostridia and drive down the production cost of 1-butanol by deploying recent advances in biotechnology and engineering. This review describes re-commercialization efforts and highlights developments in feedstock utilization, microbial strain development and fermentation process development, all of which significantly impact production costs.

Copyright © 2011 Elsevier Ltd. All rights reserved.

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