Send to:

Choose Destination
See comment in PubMed Commons below
J Am Geriatr Soc. 2011 Apr;59(4):622-7. doi: 10.1111/j.1532-5415.2010.03289.x. Epub 2011 Mar 2.

Predictors of nosocomial bloodstream infections in older adults.

Author information

  • 1Division of Infectious Diseases, Detroit Medical Center, Wayne State University, Detroit, Michigan, USA.



To identify predictors and construct a prediction model for nosocomial bloodstream infection (BSI) in older adults.


Retrospective case-control study.


Hospitals belonging to the Duke Infection Control Outreach Network.


Patients age 65 and older with a nosocomial BSI and matched uninfected controls.


Multiple variables were captured and compared between groups. Independent predictors were identified using conditional logistic regression. A prediction model and score was constructed.


Eight hundred thirty cases were compared with 830 controls. Eighty-one percent of nosocomial BSIs were catheter related (CRBSI). Methicillin-resistant Staphylococcus aureus (MRSA) was the most common pathogen isolated (23%). Independent predictors of nosocomial BSI in older adults were male sex, obesity, low McCabe score on admission, presence of a central line at admission, gastrostomy at admission, recent surgery, and urinary incontinence. A prediction model score greater than 11 (total possible score 23) was predictive of infection.


MRSA is a common cause of CRBSI in older adults. Male sex, obesity, the presence of a central line, a gastrostomy tube, and urinary incontinence at the time of admission were independent predictors of BSI in hospitalized older adults. The prediction model constructed in this study should be validated prospectively in a different cohort.

© 2011, Copyright the Authors. Journal compilation © 2011, The American Geriatrics Society.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Write to the Help Desk