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PLoS One. 2011 Feb 22;6(2):e15190. doi: 10.1371/journal.pone.0015190.

Influenza A virus hemagglutinin antibody escape promotes neuraminidase antigenic variation and drug resistance.

Author information

  • 1Laboratory of Viral Diseases, Department of Health and Human Services, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.

Abstract

Drugs inhibiting the influenza A virus (IAV) neuraminidase (NA) are the cornerstone of anti-IAV chemotherapy and prophylaxis in man. Drug-resistant mutations in NA arise frequently in human isolates, limiting the therapeutic application of NA inhibitors. Here, we show that antibody-driven antigenic variation in one domain of the H1 hemagglutinin Sa site leads to compensatory mutations in NA, resulting in NA antigenic variation and acquisition of drug resistance. These findings indicate that influenza A virus resistance to NA inhibitors can potentially arise from antibody driven HA escape, confounding analysis of influenza NA evolution in nature.

PMID:
21364978
[PubMed - indexed for MEDLINE]
PMCID:
PMC3043005
Free PMC Article
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