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J Mater Sci Mater Med. 2011 Apr;22(4):845-51. doi: 10.1007/s10856-011-4260-4. Epub 2011 Mar 1.

Carbon nanotubes linked with pitavastatin: synthesis and characterisation.

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  • 1Institute of Chemical and Environment Engineering, West Pomerania University of Technology, Szczecin, Poland.

Abstract

The paper presents a study on functionalisation of multi-walled carbon nanotubes in the area of lattice defects and an attempt to bind the nanotubes with pitavastatin. Carbon nanotubes were synthesised by alcohol-chemical vapour deposition in the presence of the catalyst Fe-Co/MgO. The nanotubes were purified and the product was subjected to chemical functionalisation. Functional groups were introduced in the reaction of the purified nanotubes with thionyl chloride to obtain acidic chlorides linked to pitavastatin. The properties and structure of the nanotubes were analysed by FT-IR and Raman spectroscopies, transmission electron microscopy and liquid chromatography coupled with mass spectrometry. Photochemical stability of pitavastatin linked with carbon nanotubes has been found to be increased.

PMID:
21360122
[PubMed - indexed for MEDLINE]
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