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Sleep. 2011 Mar 1;34(3):335-9.

Sleep deprivation increases blood pressure in healthy normotensive elderly and attenuates the blood pressure response to orthostatic challenge.

Author information

  • 1Center for Advanced Research in Sleep Medicine, Hôpital du Sacré-Coeur de Montréal, Montréal, Canada.

Abstract

STUDY OBJECTIVES:

To determine how aging affects the impact of sleep deprivation on blood pressure at rest and under orthostatic challenge.

DESIGN:

Subjects underwent a night of sleep and 24.5 h of sleep deprivation in a crossover counterbalanced design.

SETTING:

Sleep laboratory.

PARTICIPANTS:

Sixteen healthy normotensive men and women: 8 young adults (mean 24 years [SD 3.1], range 20-28 years) and 8 elderly adults (mean 64.1 years [SD 3.4], range 60-69 years).

INTERVENTIONS:

Sleep deprivation.

MEASUREMENTS AND RESULTS:

Brachial cuff arterial blood pressure and heart rate were measured in semi-recumbent and upright positions. These measurements were compared across homeostatic sleep pressure conditions and age groups. Sleep deprivation induced a significant increase in systolic and diastolic blood pressure in elderly but not young adults. Moreover, sleep deprivation attenuated the systolic blood pressure orthostatic response in both age groups.

CONCLUSIONS:

Our results suggest that sleep deprivation alters the regulatory mechanisms of blood pressure and might increase the risk of hypertension in healthy normotensive elderly.

KEYWORDS:

Sleep deprivation; aging; blood pressure; hypertension

PMID:
21358850
[PubMed - indexed for MEDLINE]
PMCID:
PMC3041709
Free PMC Article
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