Abstract
Malaria is an important public health problem in developing countries. The production of a good vaccine needs a better knowledge of different mechanisms which control the immune system. Results from donors show a higher frequency of antigens HLA: A2, B35, CW4, CW6, DRW52, DQW1 and DQW3. The lymphoproliferation in vitro of mononuclear cells, T cells and CD4+ and CD8+ subsets T cells with merozoite extracts is not so clear to establish a correlation between HLA phenotypes and T cells response.
MeSH terms
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Adult
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Animals
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Antigens, Protozoan / immunology*
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Female
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Genetic Predisposition to Disease
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HLA Antigens / analysis
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Humans
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Immunity, Cellular
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Leukocytes, Mononuclear / immunology*
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Lymphocyte Activation
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Malaria, Falciparum / prevention & control*
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Male
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Middle Aged
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Phenotype
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Plasmodium falciparum / growth & development
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Plasmodium falciparum / immunology*
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Protozoan Proteins / immunology*
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Protozoan Vaccines*
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T-Lymphocyte Subsets / immunology*
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Vaccines
Substances
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Antigens, Protozoan
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HLA Antigens
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Protozoan Proteins
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Protozoan Vaccines
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Vaccines