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Physiology (Bethesda). 2011 Feb;26(1):14-22. doi: 10.1152/physiol.00048.2010.

Role of TRP channels in the regulation of the endosomal pathway.

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  • 1Laboratory of Cell Biology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

Abstract

Some members of the transient receptor potential (TRP) channel superfamily have proved to be essential in maintaining adequate ion homeostasis, signaling, and membrane trafficking in the endosomal pathway. The unique properties of the TRP channels confer cells the ability to integrate cytosolic and intraluminal stimuli and allow maintained and regulated release of Ca(2+) from endosomes and lysosomes.

PMID:
21357899
[PubMed - indexed for MEDLINE]
PMCID:
PMC3408074
Free PMC Article
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