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Cell Metab. 2011 Mar 2;13(3):236-8. doi: 10.1016/j.cmet.2011.02.008.

Endothelium-dependent delivery of insulin to muscle interstitium.

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  • 1Research Division, Joslin Diabetes Center, Boston, MA 02215, USA.

Abstract

Insulin contributes to skeletal muscle glucose uptake by increasing blood flow and recruiting perfused capillaries. In this issue of Cell Metabolism, Kubota et al. (2011) show that deletion of IRS-2 in endothelial cells in mice causes impaired transcapillary insulin transport, decreased insulin-stimulated glucose uptake in muscle, and mild glucose intolerance.

Copyright © 2011 Elsevier Inc. All rights reserved.

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PMID:
21356512
[PubMed]
PMCID:
PMC3232062
Free PMC Article
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