Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Parasit Vectors. 2011 Feb 28;4:26. doi: 10.1186/1756-3305-4-26.

Are protozoan metacaspases potential parasite killers?

Author information

  • 1Malaria Research Unit, University Lyon 1, 8 Avenue Rockefeller, 69373 Lyon cedex 08, France.

Abstract

Mechanisms concerning life or death decisions in protozoan parasites are still imperfectly understood. Comparison with higher eukaryotes has led to the hypothesis that caspase-like enzymes could be involved in death pathways. This hypothesis was reinforced by the description of caspase-related sequences in the genome of several parasites, including Plasmodium, Trypanosoma and Leishmania. Although several teams are working to decipher the exact role of metacaspases in protozoan parasites, partial, conflicting or negative results have been obtained with respect to the relationship between protozoan metacaspases and cell death. The aim of this paper is to review current knowledge of protozoan parasite metacaspases within a drug targeting perspective.

PMID:
21356053
[PubMed - indexed for MEDLINE]
PMCID:
PMC3058108
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Write to the Help Desk