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Fertil Steril. 2011 May;95(6):1970-4. doi: 10.1016/j.fertnstert.2011.01.154. Epub 2011 Feb 26.

Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization.

Author information

  • 1Department of Obstetrics and Gynecology, Washington University, St. Louis, Missouri 63108, USA. jungheime@wudosis.wustl.edu

Abstract

OBJECTIVE:

To determine if follicular free fatty acid (FFA) levels are associated with cumulus oocyte complex (COC) morphology.

DESIGN:

Prospective cohort study.

SETTING:

University in vitro fertilization (IVF) practice.

PATIENT(S):

A total of 102 women undergoing IVF.

INTERVENTION(S):

Measurement of FFAs in serum and ovarian follicular fluid.

MAIN OUTCOME MEASURE(S):

Total and specific follicular and serum FFA levels, correlations between follicular and serum FFAs, and associations between follicular FFA levels and markers of oocyte quality, including COC morphology.

RESULT(S):

Predominant follicular fluid and serum FFAs were oleic, palmitic, linoleic, and stearic acids. Correlations between follicular and serum FFA concentrations were weak (r=0.252, 0.288, 0.236, 0.309, respectively for specific FFAs; r=0.212 for total FFAs). A receiver operating characteristic curve determined total follicular FFAs≥0.232 μmol/mL distinguished women with a lower versus higher percentage of COCs with favorable morphology. Women with elevated follicular FFAs (n=31) were more likely to have COCs with poor morphology than others (n=71; OR 3.3, 95% CI1.2-9.2). This relationship held after adjusting for potential confounders, including age, body mass index, endometriosis, and amount of gonadotropin administered (β=1.2; OR 3.4, 95% CI 1.1-10.4).

CONCLUSION(S):

Elevated follicular FFA levels are associated with poor COC morphology. Further work is needed to determine what factors influence follicular FFA levels and if these factors impact fertility.

Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

PMID:
21353671
[PubMed - indexed for MEDLINE]
PMCID:
PMC3080431
Free PMC Article
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