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Curr Opin Struct Biol. 2011 Apr;21(2):180-8. doi: 10.1016/j.sbi.2011.02.001. Epub 2011 Feb 24.

Protein function prediction: towards integration of similarity metrics.

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  • 1Department of Molecular and Human Genetics, 1 Baylor Plaza, Baylor College of Medicine, Houston, TX 77030, USA.

Abstract

Genomic centers discover increasingly many protein sequences and structures, but not necessarily their full biological functions. Thus, currently, less than one percent of proteins have experimentally verified biochemical activities. To fill this gap, function prediction algorithms apply metrics of similarity between proteins on the premise that those sufficiently alike in sequence, or structure, will perform identical functions. Although high sensitivity is elusive, network analyses that integrate these metrics together hold the promise of rapid gains in function prediction specificity.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21353529
[PubMed - indexed for MEDLINE]
PMCID:
PMC3120633
Free PMC Article

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