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Genome Biol. 2011;12(2):R19. doi: 10.1186/gb-2011-12-2-r19. Epub 2011 Feb 25.

Dating the age of admixture via wavelet transform analysis of genome-wide data.

Author information

  • 1Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, Leipzig, D-04103, Germany. irina_pugach@eva.mpg.de.

Abstract

We describe a PCA-based genome scan approach to analyze genome-wide admixture structure, and introduce wavelet transform analysis as a method for estimating the time of admixture. We test the wavelet transform method with simulations and apply it to genome-wide SNP data from eight admixed human populations. The wavelet transform method offers better resolution than existing methods for dating admixture, and can be applied to either SNP or sequence data from humans or other species.

PMID:
21352535
[PubMed - indexed for MEDLINE]
PMCID:
PMC3188801
Free PMC Article

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