Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Yao Xue Xue Bao. 2010 Dec;45(12):1509-15.

[Synthesis and HIV-1 inhibitory activity of natural products isolated from Gnetum parvifolium and their analogues].

[Article in Chinese]

Author information

  • 1Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

Abstract

Resveratrol, isorhapontigenin and pinosylvin, isolated from Gnetum parvifolium, and their analogues have been synthesized and tested for their inhibitory activity of HIV-1. Natural product 12a and analogues (12d, 12e, 12g) display significant inhibitory activity of HIV-1 replication. Among them, compound 12d (trans-3, 4, 5, 4'-tetrahydroxystilbene) exhibits the most potent anti-HIV-1 activity with an IC50 value of 1.84 micromol x L(-1).

PMID:
21351490
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk