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Yao Xue Xue Bao. 2010 Dec;45(12):1509-15.

[Synthesis and HIV-1 inhibitory activity of natural products isolated from Gnetum parvifolium and their analogues].

[Article in Chinese]

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  • 1Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.


Resveratrol, isorhapontigenin and pinosylvin, isolated from Gnetum parvifolium, and their analogues have been synthesized and tested for their inhibitory activity of HIV-1. Natural product 12a and analogues (12d, 12e, 12g) display significant inhibitory activity of HIV-1 replication. Among them, compound 12d (trans-3, 4, 5, 4'-tetrahydroxystilbene) exhibits the most potent anti-HIV-1 activity with an IC50 value of 1.84 micromol x L(-1).

[PubMed - indexed for MEDLINE]
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