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World J Gastroenterol. 2011 Feb 7;17(5):547-56. doi: 10.3748/wjg.v17.i5.547.

Recent advances in cytokines: therapeutic implications for inflammatory bowel diseases.

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  • 1Inserm UMR991, Department of Hepato-Gastroenterology, University Hospital of Rennes, Pontchaillou, 35000 Rennes, France.


Inflammatory bowel diseases (IBDs) are complex and chronic disabling conditions resulting from a dysregulated dialogue between intestinal microbiota and components of both the innate and adaptive immune systems. Cytokines are essential mediators between activated immune and non-immune cells, including epithelial and mesenchymal cells. They are immunomodulatory peptides released by numerous cells and these have significant effects on immune function leading to the differentiation and survival of T cells. The physiology of IBD is becoming a very attractive field of research for development of new therapeutic agents. These include cytokines involved in intestinal immune inflammation. This review will focus on mechanisms of action of cytokines involved in IBD and new therapeutic opportunities for these diseases.


Biological therapy; Crohn’s disease; Cytokine; Inflammatory bowel disease; Pathophysiology; Ulcerative colitis

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