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J Pediatr. 2011 Jul;159(1):57-63. doi: 10.1016/j.jpeds.2010.12.054. Epub 2011 Feb 24.

Population-based analysis of survival for hypoplastic left heart syndrome.

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  • 1Department of Surgery, University of Michigan, Ann Arbor, MI 48109-5864, USA. jhirsch@umich.edu

Abstract

OBJECTIVE:

To analyze survival patterns among infants with hypoplastic left heart syndrome (HLHS) in the State of Michigan.

STUDY DESIGN:

Cases of HLHS prevalent at live birth were identified and confirmed within the Michigan Birth Defects Registry from 1992 to 2005 (n=406). Characteristics of infants with HLHS were compared with a 10:1 random control sample.

RESULTS:

Compared with 4060 control subjects, the 406 cases of HLHS were more frequently male (62.6% vs 51.4%), born prematurely (<37 weeks gestation; 15.3% vs 8.7%), and born at low birth weight (LBW) (<2.5 kg; 16.0% vs 6.6%). HLHS 1-year survival rate improved over the study period (P=.041). Chromosomal abnormalities, LBW, premature birth, and living in a high poverty neighborhood were significantly associated with death. Controlling for neighborhood poverty, term infants versus preterm with HLHS or LBW were 3.2 times (95% CI: 1.9-5.3; P<.001) more likely to survive at least 1 year. Controlling for age and weight, infants from low-poverty versus high-poverty areas were 1.8 times (95% CI: 1.1-2.8; P=.015) more likely to survive at least 1 year.

CONCLUSIONS:

Among infants with HLHS in Michigan, those who were premature, LBW, had chromosomal abnormalities, or lived in a high-poverty area were at increased risk for early death.

Copyright © 2011 Mosby, Inc. All rights reserved.

[PubMed - indexed for MEDLINE]
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