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Arthritis Res Ther. 2011 Feb 1;13(1):101. doi: 10.1186/ar3204.

Promise and pitfalls of the Immunochip.

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  • 1University of Queensland Diamantina Institute, Brisbane, Queensland, Australia.

Abstract

Genomewide association studies (GWAS) have proven a powerful hypothesis-free method to identify common disease-associated variants. Even quite large GWAS, however, have only at best identified moderate proportions of the genetic variants contributing to disease heritability. To provide cost-effective genotyping of common and rare variants to map the remaining heritability and to fine-map established loci, the Immunochip Consortium has developed a 200,000 SNP chip that has been produced in very large numbers for a fraction of the cost of GWAS chips. This chip provides a powerful tool for immunogenetics gene mapping.

PMID:
21345260
[PubMed - indexed for MEDLINE]
PMCID:
PMC3157635
Free PMC Article
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