The ups and downs of tannins as inhibitors of poly(ADP-ribose)glycohydrolase

Christian Blenn; Philippe Wyrsch; Felix R Althaus

doi:10.3390/molecules16021854

The ups and downs of tannins as inhibitors of poly(ADP-ribose)glycohydrolase

Molecules. 2011 Feb 22;16(2):1854-77. doi: 10.3390/molecules16021854.

Authors

Christian Blenn¹, Philippe Wyrsch, Felix R Althaus

Affiliation

¹ Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Winterthurerstrasse 260, 8057 Zurich, Switzerland. blennc@vetpharm.uzh.ch

Abstract

DNA damage to cells activates nuclear poly(ADP-ribose)polymerases (PARPs) and the poly(ADP-ribose) (PAR) synthesized is rapidly cleaved into ADP-ribose (ADPR) by PAR glycohydrolase (PARG) action. Naturally appearing tannin-like molecules have been implicated in specific inhibition of the PARG enzyme. This review deals with the in vitro and in vivo effects of tannins on PAR metabolism and their downstream actions in DNA damage signaling.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Glycoside Hydrolases / antagonists & inhibitors*
Glycoside Hydrolases / genetics
Glycoside Hydrolases / metabolism
Humans
Molecular Structure
Poly Adenosine Diphosphate Ribose / chemistry
Poly Adenosine Diphosphate Ribose / metabolism
RNA Interference
Tannins / chemistry
Tannins / metabolism*

Substances

Tannins
Poly Adenosine Diphosphate Ribose
Glycoside Hydrolases
poly ADP-ribose glycohydrolase