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Int J Mol Sci. 2011 Jan 18;12(1):588-612. doi: 10.3390/ijms12010588.

Phospholipases A₁.

Author information

  • 1Agilent Technologies, Molecular Separations, Santa Clara, CA 95051, USA; E-Mail: gregoryr9@gmail.com.

Abstract

Phospholipase A(1) (PLA(1)) is an enzyme that hydrolyzes phospholipids and produces 2-acyl-lysophospholipids and fatty acids. This lipolytic activity is conserved in a wide range of organisms but is carried out by a diverse set of PLA(1) enzymes. Where their function is known, PLA(1)s have been shown to act as digestive enzymes, possess central roles in membrane maintenance and remodeling, or regulate important cellular mechanisms by the production of various lysophospholipid mediators, such as lysophosphatidylserine and lysophosphatidic acid, which in turn have multiple biological functions.

KEYWORDS:

lysophospholipid; phospholipase A1; phospholipid

PMID:
21340002
[PubMed - indexed for MEDLINE]
PMCID:
PMC3039968
Free PMC Article
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