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Biomed Opt Express. 2011 Jan 24;2(2):396-407. doi: 10.1364/BOE.2.000396.

Non-contact spectroscopic determination of large blood volume fractions in turbid media.

Abstract

We report on a non-contact method to quantitatively determine blood volume fractions in turbid media by reflectance spectroscopy in the VIS/NIR spectral wavelength range. This method will be used for spectral analysis of tissue with large absorption coefficients and assist in age determination of bruises and bloodstains. First, a phantom set was constructed to determine the effective photon path length as a function of μ(a) and μ(s)' on phantoms with an albedo range: 0.02-0.99. Based on these measurements, an empirical model of the path length was established for phantoms with an albedo > 0.1. Next, this model was validated on whole blood mimicking phantoms, to determine the blood volume fractions ρ = 0.12-0.84 within the phantoms (r = 0.993; error < 10%). Finally, the model was proved applicable on cotton fabric phantoms.

KEYWORDS:

(000.1430) Biology and medicine; (170.1470) Blood or tissue constituent monitoring; (300.1030) Spectroscopy

PMID:
21339884
[PubMed]
PMCID:
PMC3038454
Free PMC Article

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