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Magn Reson Med. 2011 Mar;65(3):744-9. doi: 10.1002/mrm.22667. Epub 2010 Dec 2.

Validation of VASO cerebral blood volume measurement with positron emission tomography.

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  • 1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.


Cerebral blood volume (CBV) has been shown to be an important biomarker in a number of neurological disorders and in the quantitative interpretation of functional MRI. One approach to determine CBV in humans is vascular-space-occupancy MRI, and this technique has been applied to the studies of brain glioma, Schizophrenia, and Alzheimer's disease. However, validation of this technique with a gold standard method has not been reported. In this study, we compared vascular-space-occupancy MRI with a radiotracer-based positron emission tomography technique in a group of healthy subjects. It was found that regional CBV measured with vascular-space-occupancy MRI was highly correlated with that of the positron emission tomography data (R=0.79±0.10, N=8). Furthermore, absolute CBV values quantified by vascular-space-occupancy were also in excellent agreement with those by positron emission tomography (slope=1.00±0.15). Because of the differences in the labeling principles between the two modalities, systematic CBV differences were observed in large vessel and ventricle regions.

Copyright © 2010 Wiley-Liss, Inc.

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