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EMBO J. 2011 Mar 16;30(6):1149-61. doi: 10.1038/emboj.2011.35. Epub 2011 Feb 18.

CESTA, a positive regulator of brassinosteroid biosynthesis.

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  • 1Centre for Novel Agricultural Products, Department of Biology, University of York, York, UK. brigitte.poppenberger@univie.ac.at

Abstract

Brassinosteroids (BRs) are steroid hormones that are essential for the development of plants. A tight control of BR homeostasis is vital for modulating their impact on growth responses. Although it is recognized that the rapid adaptation of de novo synthesis has a key role in adjusting required BR levels, our knowledge of the mechanisms governing feedback control is limited. In this study, we identify the transcription factor CESTA as a regulator of BR biosynthesis. ces-D was isolated in a screen of Arabidopsis mutants by BR over-accumulation phenotypes. Loss-of-function analysis and the use of a dominant repressor version revealed functional overlap among CESTA and its homologues and confirmed the role of CESTA in the positive control of BR-biosynthetic gene expression. We provide evidence that CESTA interacts with its homologue BEE1 and can directly bind to a G-box motif in the promoter of the BR biosynthesis gene CPD. Moreover, we show that CESTA subnuclear localization is BR regulated and discuss a model, in which CESTA interplays with BEE1 to control BR biosynthesis and other BR responses.

PMID:
21336258
[PubMed - indexed for MEDLINE]
PMCID:
PMC3061039
Free PMC Article
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