Stud Health Technol Inform. 2011;163:691-5.

Three dimensional projection environment for molecular design and surgical simulation.

Wickstrom E, Chen CP, Devadhas D, Wampole M, Jin YY, Sanders JM, Kairys JC, Ankeny ML, Hu R, Barner KE, Steiner KV, Thakur ML.

Source

Biochemistry & Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

Abstract

We are developing agents for positron emission tomography (PET) imaging of cancer gene mRNA expression and software to fuse mRNA PET images with anatomical computerized tomography (CT) images to enable volumetric (3D) haptic (touch-and-feel) simulation of pancreatic cancer and surrounding organs prior to surgery in a particular patient. We have identified a novel ligand specific for epidermal growth factor receptor (EGFR) to direct PET agent uptake specifically into cancer cells, and created a volumetric haptic surgical simulation of human pancreatic cancer reconstructed from patient CT data. Young's modulus and the Poisson ratio for each tissue will be adjusted to fit the experience of participating surgeons.

PMID:: 21335882; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH Terms

Substances

Radiopharmaceuticals

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