Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Microbiol. 2011 Apr;14(2):142-7. doi: 10.1016/j.mib.2011.01.012. Epub 2011 Feb 19.

Regulation of gene expression by reiterative transcription.

Author information

  • Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294-2170, USA. chuckt@uab.edu

Abstract

Gene regulation involves many different types of transcription control mechanisms, including mechanisms based on reiterative transcription in which nucleotides are repetitively added to the 3' end of a nascent transcript due to upstream transcript slippage. In these mechanisms, reiterative transcription is typically modulated by interactions between RNA polymerase and its nucleoside triphosphate substrates without the involvement of regulatory proteins. This review describes the current state of knowledge of gene regulation involving reiterative transcription. It focuses on the methods by which reiterative transcription is controlled and emphasizes the different fates of transcripts produced by this reaction. The review also includes a discussion of possible new and fundamentally different mechanisms of gene regulation that rely on conditional reiterative transcription.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21334966
[PubMed - indexed for MEDLINE]
PMCID:
PMC3078970
Free PMC Article

Images from this publication.See all images (3)Free text

Figure 1
Figure 2
Figure 3
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk