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    Cancer Lett. 2011 Apr 28;303(2):99-107. Epub 2011 Feb 22.

    Silencing of 14-3-3ζ over-expression in hepatocellular carcinoma inhibits tumor growth and enhances chemosensitivity to cis-diammined dichloridoplatium.

    Choi JE, Hur W, Jung CK, Piao LS, Lyoo K, Hong SW, Kim SW, Yoon HY, Yoon SK.

    Source

    WHO Collaborating Center of Viral Hepatitis, The Catholic University of Korea, Seoul 137-701, Republic of Korea.

    Abstract

    The 14-3-3ζ protein plays a key role in regulation of cellular processes. In the present study, we showed that 14-3-3ζ protein was significantly overexpressed in hepatoma cell lines and human tumorous tissues of hepatocellular carcinoma (HCC) patients. Knockdown with RNA interference in hepatoma cell lines with high 14-3-3ζ expression suppressed tumor cell proliferation via activation of c-Jun N-terminal kinase (JNK) and p38/MAPK. Furthermore, suppression of 14-3-3ζ enhanced the anti-cancer effect of cis-diammined dichloridoplatium (CDDP) in hepatoma cell lines. These results suggest that silencing of 14-3-3ζ may be an attractive target for HCC therapeutic development.

    Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

    PMID:
    21334806
    [PubMed - indexed for MEDLINE]

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