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    Curr Opin Struct Biol. 2011 Apr;21(2):265-73. doi: 10.1016/j.sbi.2011.01.008. Epub 2011 Feb 18.

    Near-atomic resolution reconstructions of icosahedral viruses from electron cryo-microscopy.

    Grigorieff N, Harrison SC.

    Source

    Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02154, USA.

    Abstract

    Nine different near-atomic resolution structures of icosahedral viruses, determined by electron cryo-microscopy and published between early 2008 and late 2010, fulfil predictions made 15 years ago that single-particle cryo-EM techniques could visualize molecular detail at 3-4Å resolution. This review summarizes technical developments, both in instrumentation and in computation, that have led to the new structures, which advance our understanding of virus assembly and cell entry.

    Copyright © 2011 Elsevier Ltd. All rights reserved.

    PMID:
    21333526
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3088881
    Free PMC Article

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