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Curr Opin Struct Biol. 2011 Apr;21(2):265-73. doi: 10.1016/j.sbi.2011.01.008. Epub 2011 Feb 18.

Near-atomic resolution reconstructions of icosahedral viruses from electron cryo-microscopy.

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  • 1Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, MA 02154, USA.

Abstract

Nine different near-atomic resolution structures of icosahedral viruses, determined by electron cryo-microscopy and published between early 2008 and late 2010, fulfil predictions made 15 years ago that single-particle cryo-EM techniques could visualize molecular detail at 3-4Å resolution. This review summarizes technical developments, both in instrumentation and in computation, that have led to the new structures, which advance our understanding of virus assembly and cell entry.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21333526
[PubMed - indexed for MEDLINE]
PMCID:
PMC3088881
Free PMC Article

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