Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Biol Direct. 2011 Feb 18;6:11. doi: 10.1186/1745-6150-6-11.

The role of duplications in the evolution of genomes highlights the need for evolutionary-based approaches in comparative genomics.

Author information

  • 1INRA, UMR1163 de Biotechnologie des Champignons Filamenteux, IFR86-BAIM, Universités de Provence et de la Méditerranée, ESIL, 163 avenue de Luminy, CP 925, 13288 Marseille Cedex 09, France. Anthony.Levasseur@esil.univmed.fr

Abstract

Understanding the evolutionary plasticity of the genome requires a global, comparative approach in which genetic events are considered both in a phylogenetic framework and with regard to population genetics and environmental variables. In the mechanisms that generate adaptive and non-adaptive changes in genomes, segmental duplications (duplication of individual genes or genomic regions) and polyploidization (whole genome duplications) are well-known driving forces. The probability of fixation and maintenance of duplicates depends on many variables, including population sizes and selection regimes experienced by the corresponding genes: a combination of stochastic and adaptive mechanisms has shaped all genomes. A survey of experimental work shows that the distinction made between fixation and maintenance of duplicates still needs to be conceptualized and mathematically modeled. Here we review the mechanisms that increase or decrease the probability of fixation or maintenance of duplicated genes, and examine the outcome of these events on the adaptation of the organisms.

PMID:
21333002
[PubMed - indexed for MEDLINE]
PMCID:
PMC3052240
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Write to the Help Desk