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Curr Opin Genet Dev. 2011 Apr;21(2):154-9. doi: 10.1016/j.gde.2011.01.016. Epub 2011 Feb 15.

The contribution of epigenetic memory to immunologic memory.

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  • 1Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States.

Abstract

Memory T lymphocytes are distinct from antigen-inexperienced naïve T cells in that memory T cells can respond more rapidly when they re-encounter a pathogen. Work over the past decade has begun to define the epigenetic underpinnings of the transcriptional component of the memory T cell response. An emerging theme is the persistence of an active chromatin signature at relevant gene loci in resting memory T cells, even when those genes are transcriptionally inactive. This gives strength to the concept of gene poising, and has shown that memory T lymphocytes are an ideal model in which to further define various mechanisms of epigenetic poising.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21330128
[PubMed - indexed for MEDLINE]
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