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Am J Ind Med. 2011 Jun;54(6):450-60. doi: 10.1002/ajim.20932. Epub 2011 Feb 15.

Distinguishing the common components of oil- and water-based metalworking fluids for assessment of cancer incidence risk in autoworkers.

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  • 1Environmental Health Sciences, University of California Berkeley, Berkeley, California 94720-7360, USA.

Abstract

BACKGROUND:

Metalworking fluids (MWF)--straight, soluble, and synthetic--have overlapping components. We derived constituent-based metrics of polycyclic aromatic hydrocarbons (PAHs), water-based MWF, biocides, and nitrosamines to account for this overlap and examined their relations with cancer incidence.

METHODS:

An autoworkers cohort of 30,000 was followed for cancer incidence. Hazard ratios were estimated for each cancer and cumulative exposure (lagged) to each new metric; soluble MWF contributed variably to several metrics with weight k = 0-1.

RESULTS:

For most cancer sites, the constituent-based metrics resulted in stronger exposure-disease associations than the MWF classes alone. Laryngeal and bladder cancer were most strongly associated with PAH (k = 0). Protective effects for stomach and lung cancer were observed with biocide, a component that may be a surrogate for endotoxin.

CONCLUSIONS:

Our findings provide support and clarification of possible etiologies for previous positive associations and provide support for distinguishing exposure from oil- and water-based MWF in epidemiologic studies.

Copyright © 2011 Wiley-Liss, Inc.

PMID:
21328414
[PubMed - indexed for MEDLINE]
PMCID:
PMC3301446
Free PMC Article
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