Transcription. 2010 Jul-Aug;1(1):32-5.

Transcriptional regulation underlying recovery from a DNA damage-induced arrest.

Alvarez-Fernández M, Medema RH, Lindqvist A.

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UMC Utrecht, the Netherlands.

Abstract

When the DNA of a cell is damaged, cell cycle progression is arrested and cell cycle-specific transcription is inhibited. However, cell cycle-specific transcription is required for eventual recovery from the DNA damage-induced arrest. Here we discuss recent findings that demonstrate how transcription is fine-tuned during the DNA damage response and how this controls the capacity to recover from a DNA damage arrest in G(2) phase.

PMID:: 21327155; [PubMed - indexed for MEDLINE]
PMCID:: PMC3035183

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