Abstract
The structure of the mitochondrial transcription termination factor (MTERF1) provides novel insight into the mechanism of binding, recognition of the termination sequence and the conformational changes involved in mediating termination. Besides its functional implications, this structure provides a framework to understand the consequences of numerous diseases associated with mitochondrial DNA mutations.
Keywords:
MTERF; POLRMT; base-flipping; gene expression; mitochondria; mitochondrial transcription termination; polarity.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Basic-Leucine Zipper Transcription Factors / chemistry
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Basic-Leucine Zipper Transcription Factors / metabolism*
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Binding Sites / genetics
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DNA, Mitochondrial / chemistry
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DNA, Mitochondrial / genetics*
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DNA, Mitochondrial / metabolism*
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Humans
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Mitochondrial Proteins / chemistry
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Mitochondrial Proteins / metabolism*
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Models, Molecular
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Nucleic Acid Conformation
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Protein Binding
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Protein Structure, Tertiary
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Terminator Regions, Genetic / genetics
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Transcription, Genetic*
Substances
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Basic-Leucine Zipper Transcription Factors
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DNA, Mitochondrial
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MTERF1 protein, human
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Mitochondrial Proteins