Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Transcription. 2010 Sep-Oct;1(2):70-5. doi: 10.4161/trns.1.2.12232.

Keeping up to speed with the transcription termination factor Rho motor.

Author information

  • 1Centre National de la Recherche Scientifique - UPR, Orléans, France. boudvillain@cnrs-orleans.fr


In bacteria, a subset of transcription termination events requires the participation of the transcription termination factor Rho. Rho is a homo-hexameric, ring-shaped, motor protein that uses the energy derived from its RNA-dependent ATPase activity to directionally unwind RNA and RNA-DNA helices and to dissociate transcription elongation complexes. Despite a wealth of structural, biochemical and genetic data, the molecular mechanisms used by Rho to carry out its biological functions remain poorly understood. Here, we briefly discuss the most recent findings on Rho mechanisms and function and highlight important questions that remain to be addressed.


RNA; helicase; hexamer; molecular motor; transcription termination

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Landes Bioscience Icon for PubMed Central
    Loading ...
    Write to the Help Desk