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Magnes Res. 1990 Dec;3(4):255-61.

Deleterious effects of high magnesium diets and beneficial effects of high potassium diets in hypertensive stroke-prone rats.

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  • 1Renal and Hypertension Section, University of Minnesota Hospital and School of Medicine, Minneapolis 55455.


The effect of varying amounts of dietary magnesium (Mg) in conjunction with potassium (K) on hypertension and stroke mortality in hypertensive stroke-prone (SHRsp) rats was studied. These results show that high K (2.1%) diets strongly protect against stroke mortality and rises of blood pressure, while high Mg (0.26%) diets appeared to increase stroke mortality and accelerate the rise of blood pressure in SHRsp rats. Similarly, medium high (1.3%) levels of K in the diet significantly reduced blood pressure and stroke mortality but not nearly as much as the 2.1% K in the high K diet.

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